PHW Newsletter - Edition 23

A Word from Jami Mann, PA

Cognitive Health and Neurodegenerative Disease

Lifespan is how long you live while healthspan is how long you live well. Neurodegenerative diseases like dementia and Alzheimer’s don’t happen overnight—they develop slowly over years, often stemming from long-term inflammation, blood sugar problems, poor sleep, chronic stress, and nutrient deficiencies.

Genetics can play a role. At PHW, we can test your APOE gene, which influences how your body handles cholesterol and repairs the brain. Carrying APOE4 increases the risk of Alzheimer’s, but it doesn’t mean you will get the disease, just that your prevention strategy should be more aggressive.

Prevention Strategies within the 5 Pillars of Health

1. Sleep

Even short-term sleep deprivation can increase inflammation and raise Alzheimer’s-related proteins like amyloid-beta. During deep sleep, the brain’s glymphatic system flushes out harmful proteins and toxins. A recent study [1] found that individuals with poor sleep characteristics showed more signs of brain atrophy.

2. Nutrition

Studies [2] show that people with metabolic syndrome are three to four times more likely to develop memory problems later in life. We can identify insulin resistance with routine lab work and implement nutritional strategies.

3. Movement

Inactivity increases dementia risk by about 40% [4]. Exercise boosts BDNF (Brain-Derived Neurotrophic Factor), which promotes neuroplasticity. For the greatest brain benefits, combine different types of exercise—including cardio, strength training, and mentally engaging activities.

4. Stress

Chronic stress raises cortisol and excitatory neurotransmitters like glutamate, which can damage brain cells. A major study in JAMA Neurology [5] found that individuals with stress-related disorders had significantly higher risk of developing neurodegenerative diseases.

5. Detox

When the body’s natural ability to detoxify is reduced, harmful substances can build up and damage the brain. A 2019 review [3] explains how exposure to heavy metals can increase oxidative stress and inflammation in the brain.

Vital Nutrients for Brain Health

• Omega MD: Omega-3 Fatty Acids help build and protect brain cell membranes, reduce inflammation, and support communication between brain cells.
• Creatine MD: Acts as an energy reserve for brain cells, reducing inflammation and supporting mental clarity.
• Methylated B Vitamins: B12, B6, and folate help convert homocysteine, which can contribute to brain atrophy when elevated.
• BrainMag MD: Magnesium Threonate crosses the blood-brain barrier to enhance brain cell communication and improve learning and memory.

By focusing on the 5 Pillars of Health—sleep, nutrition, movement, stress management, and detoxification—you can significantly lower inflammation, improve metabolic health, and strengthen cognitive resilience. At PHW, our goal is to help you take proactive steps to preserve both your lifespan and your healthspan.